Identification and characterization of binding sites for human urotensin-II in Sprague-Dawley rat renal medulla using quantitative receptor autoradiography.

@article{Disa2006IdentificationAC,
  title={Identification and characterization of binding sites for human urotensin-II in Sprague-Dawley rat renal medulla using quantitative receptor autoradiography.},
  author={Jyoti Disa and Latitia E Floyd and Richard M. Edwards and Stephen A. Douglas and Nambi V. Aiyar},
  journal={Peptides},
  year={2006},
  volume={27 6},
  pages={1532-7}
}
Urotensin-II (U-II), a ligand for the G-protein-coupled receptor UT, has been characterized as the most potent mammalian vasoconstrictor identified to date. Although circulating levels of U-II are altered in lower species (e.g., fish) upon exposure to hypo-osmotic stress, little is known about the actions of this cyclic undecapeptide within the kidney, an organ that plays a pivotal role in the control of cardiovascular homeostasis, influencing both cardiac preload (plasma volume) and after load… CONTINUE READING