Identification and characterization of an operon in Salmonella typhimurium involved in thiamine biosynthesis.

@article{Petersen1997IdentificationAC,
  title={Identification and characterization of an operon in Salmonella typhimurium involved in thiamine biosynthesis.},
  author={Louise Petersen and Diana M Downs},
  journal={Journal of bacteriology},
  year={1997},
  volume={179 15},
  pages={4894-900}
}
Thiamine pyrophosphate (TPP) is synthesized de novo in Salmonella typhimurium and is a required cofactor for many enzymes in the cell. Five kinase activities have been implicated in TPP synthesis, which involves joining a 4-methyl-5-(beta-hydroxyethyl)thiazole (THZ) moiety and a 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) moiety. We report here identification of a 2-gene operon involved in thiamine biosynthesis and present evidence that the genes in this operon, thiMD, encode two… CONTINUE READING

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