Identification and characterization of an iron-regulated hemopexin receptor in Haemophilus influenzae type b.

@article{Wong1994IdentificationAC,
  title={Identification and characterization of an iron-regulated hemopexin receptor in Haemophilus influenzae type b.},
  author={Jiafei Wong and John D. Holland and Thomas Parsons and Alyssa Smith and Paul D. Williams},
  journal={Infection and immunity},
  year={1994},
  volume={62 1},
  pages={
          48-59
        }
}
Heme can serve Haemophilus influenzae as a source of both essential porphyrin and iron. In extracellular mammalian body fluids neither free heme nor free iron is available, since they are tightly bound to hemopexin and transferrin, respectively. Since H. influenzae grows in the presence of iron-transferrin and heme-hemopexin and is known to express a saturable receptor for transferrin, we investigated the process by which this pathogen acquired heme from hemopexin for use as an iron source. The… CONTINUE READING