Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids.

@article{ParkerBarnes2000IdentificationAC,
  title={Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids.},
  author={Jennifer M. Parker-Barnes and T. K. Das and Emil G. Bobik and Amanda E. Leonard and Jennifer M. Thurmond and L T Chaung and Yihua Huang and Pradip Mukerji},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 15},
  pages={8284-9}
}
The enzymes that are involved in the elongation of fatty acids differ in terms of the substrates on which they act. To date, the enzymes specifically involved in the biosynthesis of polyunsaturated fatty acids have not yet been identified. In an attempt to identify a gene(s) encoding an enzyme(s) specific for the elongation of gamma-linolenic acid (GLA) (18:3n-6), a cDNA expression library was made from the fungus Mortierella alpina. The cDNA library constructed in a yeast expression vector was… CONTINUE READING
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