Identification and characterization of an alternative cytotoxic T lymphocyte-associated protein 4 binding molecule on B cells.

@article{Murakami1996IdentificationAC,
  title={Identification and characterization of an alternative cytotoxic T lymphocyte-associated protein 4 binding molecule on B cells.},
  author={Masashi Murakami and Yasuhiro Takahashi and Y Isashi and Shin-ichiro Kon and Wen Yi Jia and Manabu Inobe and Ryo Abe and Toshimitu Uede},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 15},
  pages={7838-42}
}
To determine whether alternative cytotoxic T lymphocyte-associated protein 4 (CTLA4) binding proteins exist on B cells, we constructed (i) mCTLA4hIgG consisting of the extracellular region of a mouse CTLA4 molecule and the Fc portion of a human IgG1 molecule and (ii) PYAAhIgG, a mutant mCTLA4hIgG, having two amino acid substitutions on the conserved MYPPPY motif in the complementarity-determining region 3-like region and lacking detectable binding to both B7-1 and B7-2 molecules. Using these… CONTINUE READING

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