Identification and characterization of an agonistic aptamer against the T cell costimulatory receptor, OX40.

Abstract

Induction of an effective immune response that can target and eliminate malignant cells or virus-infected cells requires the stimulation of antigen-specific effector T cells. A productive and long-lasting memory response requires 2 signals: a specific signal provided by antigen recognition through engagement of the T cell receptor and a secondary signal via… (More)
DOI: 10.1089/nat.2012.0388

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