Identification and characterization of an IkappaB kinase.

  title={Identification and characterization of an IkappaB kinase.},
  author={Catherine H. R{\'e}gnier and Ho Yeong Song and Xiong Zhuo Gao and David V. Goeddel and Zhaodan Cao and Mike Rothe},
  volume={90 2},
Activation of the transcription factor NF-kappaB by tumor necrosis factor (TNF) and interleukin-1 (IL-1) requires the NF-kappaB-inducing kinase (NIK). In a yeast two-hybrid screen for NIK-interacting proteins, we have identified a protein kinase previously known as CHUK. Overexpression of CHUK activates a NF-kappaB-dependent reporter gene. A catalytically inactive mutant of CHUK is a dominant-negative inhibitor of TNF-, IL-1-, TRAF-, and NIK-induced NF-kappaB activation. CHUK associates with… CONTINUE READING
88 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 88 extracted citations

Similar Papers

Loading similar papers…