Identification and characterization of a second CD4-like gene in teleost fish.

@article{Dijkstra2006IdentificationAC,
  title={Identification and characterization of a second CD4-like gene in teleost fish.},
  author={Johannes M Dijkstra and Tomonori Somamoto and L. Ted Moore and Ivar Hordvik and Mitsuru Ototake and Uwe Fischer},
  journal={Molecular immunology},
  year={2006},
  volume={43 5},
  pages={410-9}
}
In fish, T cell subdivision is not well studied, although CD8 and CD4 homologues have been reported. This study describes a second teleost CD4-like gene, CD4-like 2 (CD4L-2). Two rainbow trout copies of this gene were found, -2a and -2b, encoding molecules sharing 81% aa identity. The 2a/2b duplication may be related to tetraploid ancestry of salmonid fishes. In the Fugu genome CD4L-2 lies head to tail with an earlier reported, very different CD4-like gene [Suetake, H., Araki, K., Suzuki, Y… CONTINUE READING
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