Identification and characterization of a transcriptional regulator for the lck proximal promoter.

@article{Yamada2001IdentificationAC,
  title={Identification and characterization of a transcriptional regulator for the lck proximal promoter.},
  author={Aki Yamada and Sachiko Takaki and Fumihiko Hayashi and Katia Georgopoulos and Roger M. Perlmutter and Kiyoshi Takatsu},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 21},
  pages={18082-9}
}
The lck gene encodes a protein-tyrosine kinase that plays a key role in signaling mediated through T cell receptor (TCR) and pre-TCR complexes. Transcription of the lck gene is regulated by two independent promoter elements: the proximal and distal promoters. Previous studies employing transgenic mice demonstrated that the sequence between -584 and -240… CONTINUE READING