Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes.

@article{Rodrguez2002IdentificationAC,
  title={Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes.},
  author={A Rodr{\'i}guez and Barbara Perron and Ludovic Lacroix and Bernard Caillou and G{\'e}rard Leblanc and Martin Schlumberger and J M Bidart and Thierry Pourcher},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 7},
  pages={3500-3}
}
Iodide transport by thyrocytes is a two step process involving transporters located either in the basal or in the apical membranes of the cell. The sodium iodide symporter (NIS) is localized in the basolateral membrane facing the bloodstream and mediates iodide accumulation into thyrocytes. Pendrin has been proposed as an apical transporter. In order to identify new iodide transporters, we developed a PCR cloning strategy based on NIS sequence homologies. From a human kidney cDNA library, we… CONTINUE READING
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