Identification and characterization of a primary antibacterial domain in CAP18, a lipopolysaccharide binding protein from rabbit leukocytes.

@article{Tossi1994IdentificationAC,
  title={Identification and characterization of a primary antibacterial domain in CAP18, a lipopolysaccharide binding protein from rabbit leukocytes.},
  author={Alessandro Tossi and Marco Scocchi and Barbara Skerlavaj and Renato Gennaro},
  journal={FEBS letters},
  year={1994},
  volume={339 1-2},
  pages={108-12}
}
Secondary structure prediction studies on CAP18, a lipopolysaccharide binding protein from rabbit granulocytes, identified a highly cationic, 21-residue sequence with the tendency to adopt an amphipathic alpha-helical conformation, as observed in many antimicrobial peptides. The corresponding peptide was chemically synthesized and shown to exert a potent bactericidal activity against both Gram-negative and Gram-positive bacteria, and a rapid permeabilization of the inner membrane of Escherichia… CONTINUE READING