Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors.

@article{Lee2007IdentificationAC,
  title={Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors.},
  author={Hey-Kyoung Lee and Kogo Takamiya and Kimihiko Kameyama and Kaiwen He and Sandy Yu and Luciano Rossetti and David Wilen and Richard L. Huganir},
  journal={Molecular and cellular neurosciences},
  year={2007},
  volume={36 1},
  pages={86-94}
}
Phosphorylation of various AMPA receptor subunits can alter synaptic transmission and plasticity at excitatory glutamatergic synapses in the central nervous system. Here, we identified threonine-840 (T840) on the GluR1 subunit of AMPA receptors as a novel phosphorylation site. T840 is phosphorylated by protein kinase C (PKC) in vitro and is a highly turned-over phosphorylation site in the hippocampus. Interestingly, the high basal phosphorylation of T840 in the hippocampus is maintained by a… CONTINUE READING

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Developmental switch in synaptic Please cite this article as: Lee, H.-K., et al., Identification and characterization o Mol. Cell

  • E. D. Nosyreva, K. M. Huber
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