Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors

@article{Lee2007IdentificationAC,
  title={Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors},
  author={Hey-Kyoung Lee and Kogo Takamiya and Kimihiko Kameyama and Kaiwen He and Richard L. Huganir},
  journal={Molecular and Cellular Neuroscience},
  year={2007},
  volume={36},
  pages={86-94}
}
  • Hey-Kyoung Lee, Kogo Takamiya, +2 authors Richard L. Huganir
  • Published 2007
  • Medicine, Biology
  • Molecular and Cellular Neuroscience
  • Phosphorylation of various AMPA receptor subunits can alter synaptic transmission and plasticity at excitatory glutamatergic synapses in the central nervous system. Here, we identified threonine-840 (T840) on the GluR1 subunit of AMPA receptors as a novel phosphorylation site. T840 is phosphorylated by protein kinase C (PKC) in vitro and is a highly turned-over phosphorylation site in the hippocampus. Interestingly, the high basal phosphorylation of T840 in the hippocampus is maintained by a… CONTINUE READING

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    Control of GluR1 AMPA Receptor Function by cAMP-Dependent Protein Kinase

    VIEW 2 EXCERPTS

    Cyclic AMP and synaptic activity-dependent phosphorylation of AMPA- preferring glutamate receptors

    VIEW 2 EXCERPTS