Identification and characterization of a novel family of Drosophilaβ‐adrenergic‐like octopamine G‐protein coupled receptors

  title={Identification and characterization of a novel family of Drosophila$\beta$‐adrenergic‐like octopamine G‐protein coupled receptors},
  author={Braudel Maqueira and Heather Chatwin and Peter D. Evans},
  journal={Journal of Neurochemistry},
Insect octopamine receptors carry out many functional roles traditionally associated with vertebrate adrenergic receptors. These include control of carbohydrate metabolism, modulation of muscular tension, modulation of sensory inputs and modulation of memory and learning. The activation of octopamine receptors mediating many of these actions leads to increases in the levels of cyclic AMP. However, to date none of the insect octopamine receptors that have been cloned have been convincingly shown… 

Insect octopamine receptors: a new classification scheme based on studies of cloned Drosophila G-protein coupled receptors

In future studies on the molecular basis of octopamine signalling in individual tissues it will be essential to identify the relative expression levels of the different classes ofOctopamine receptor present to identify if co-expression of such receptors in the same cells results in the formation of oligomeric receptors with specific emergent pharmacological and signalling properties.

AmOctα2R: Functional Characterization of a Honeybee Octopamine Receptor Inhibiting Adenylyl Cyclase Activity

The functional characterization of AmOctα2R adds a sixth member to this subfamily of monoaminergic receptors in the honeybee and is an important step towards understanding the actions of octopamine in honeybee behavior and physiology.

Two splicing variants of a novel family of octopamine receptors with different signaling properties

The functional characterization of one putative octopamine/tyramine receptor gene from the rice stem borer, Chilo suppressalis, is described and it is confirmed that CsOA3 has a different pharmacological profile from that of otherOctopamine receptor families.

A new Drosophila octopamine receptor responds to serotonin.

A comparison of the signalling properties of two tyramine receptors from Drosophila

The structurally related receptor, CG16766, was internalized by a number of biogenic amines, including octopamine, dopamine, noradrenaline, adrenaline, which also were able to elevate cyclic AMP levels and is proposed to represent a new group of tyramine receptors, which is designated the Tyramine 3 receptors.

PaOctβ2R: Identification and Functional Characterization of an Octopamine Receptor Activating Adenylyl Cyclase Activity in the American Cockroach Periplaneta americana

The functional characterization of PaOctβ2R and the bioinformatics data uncovered that the monoaminergic receptor family in the hemimetabolic P. americana is similarly complex as in holometabolic model insects like Drosophila melanogaster and the honeybee, Apis mellifera.

Characterization of a β-adrenergic-like octopamine receptor from the rice stem borer (Chilo suppressalis)

A rather unique pharmacological profile for CsOA2B2 is observed through measurements of cAMP, the invertebrate counterpart of adrenaline and noradrenaline, which is important for a better functional understanding of this receptor as well as for practical applications in the development of environmentally sustainable pesticides.

Rapid, Nongenomic Responses to Ecdysteroids and Catecholamines Mediated by a Novel Drosophila G-Protein-Coupled Receptor

DmDopEcR can function as a cell-surface GPCR that may be responsible for some of the rapid, nongenomic actions of ecdysteroids, during both development and signaling in the mature adult nervous system.

Molecular, pharmacological, and signaling properties of octopamine receptors from honeybee (Apis mellifera) brain

The subroot of octopamine receptors activating adenylyl cyclases is the largest that has so far been characterized in arthropods, and it should now be possible to unravel the contribution of individual receptors to the physiology and behavior of honeybees.



A family of octapamine receptors that specifically induce cyclic AMP production or Ca2+ release in Drosophila melanogaster

The functional characterization of two genes from Drosophila melanogaster that encode unique receptors that display signature properties of native octopamine receptors are described.

Cloning, localization, and permanent expression of a Drosophila octopamine receptor

A Novel Octopamine Receptor with Preferential Expression inDrosophila Mushroom Bodies

The preferential expression of OAMB in mushroom bodies and its capacity to produce cAMP accumulation suggest an important role in synaptic modulation underlying behavioral plasticity.

Octopamine receptor subtypes and their modes of action

The current status of this classification is reviewed by examining the pharmacology of responses to octopamine in a range of preparations and it is concluded that the distinction between OCTOPAMINE1 and OCTopAMINE2 receptor types is still valid, but that OCTOPamINE2 receptors exhibit some tissue specific variations.

Agonist‐specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems.

A cloned seven transmembrane‐spanning Drosophila octopamine/tyramine receptor, permanently expressed in a Chinese hamster ovary cell line, both inhibits adenylate cyclase activity and leads to the

Activation of a heterologously expressed octopamine receptor coupled only to adenylyl cyclase produces all the features of presynaptic facilitation in aplysia sensory neurons.

  • D. ChangX. Li B. Kaang
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2000
Results indicate that the cAMP/PKA pathway alone is sufficient to produce all the features of presynaptic facilitation.

Agonist-Specific Coupling of a Cloned Drosophila melanogaster D1-Like Dopamine Receptor to Multiple Second Messenger Pathways by Synthetic Agonists

The receptor exhibits agonist-specific coupling to second messenger systems for synthetic agonists, which could provide a useful tool in the genetic analysis of the roles of the multiple second messenger pathways activated by this receptor, given the likely involvement of dopamine in the processes of learning and memory in the insect nervous system.

Characterization of Drosophila Tyramine β-HydroxylaseGene and Isolation of Mutant Flies Lacking Octopamine

The molecular cloning of the Drosophila melanogaster gene, which encodes tyramine β-hydroxylase (TBH), the enzyme that catalyzes the last step in octopamine biosynthesis, is reported, and the deduced amino acid sequence of the encoded protein exhibits 39% identity to the evolutionarily related mammalian dopamine β-Hydroxylases enzyme.

The Metabotropic GABAB Receptor Directly Interacts with the Activating Transcription Factor 4*

It is demonstrated that inhibitory metabotropic GABABRs may regulate activity-dependent gene expression via a direct interaction with ATF-4, a member of the cAMP response element-binding protein /ATF family.