Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha.

@article{Burke1998IdentificationAC,
  title={Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha.},
  author={Les J Burke and Michael Downes and Vincent Laudet and George E. O. Muscat},
  journal={Molecular endocrinology},
  year={1998},
  volume={12 2},
  pages={248-62}
}
Rev-erbA alpha and RVR are orphan nuclear receptors that function as dominant transcriptional silencers. Ligand-independent repression of transcription by Rev-erbA alpha and RVR is mediated by the nuclear receptor corepressors, N-CoR and its variants RIP (RXR interacting protein) 13a and RIP13 delta 1. The physical association between the corepressors and Rev-erbA alpha and RVR is dependent on the presence of a receptor interaction domain (RID) in the N-CoR family. Our previous study… CONTINUE READING
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