Identification and characterization of a novel RanGTP-binding protein in the yeast Saccharomyces cerevisiae.

@article{Braunwarth2003IdentificationAC,
  title={Identification and characterization of a novel RanGTP-binding protein in the yeast Saccharomyces cerevisiae.},
  author={Andreas Braunwarth and Micheline Fromont-Racine and Pierre Legrain and F. Ralf Bischoff and Thomas Gerstberger and Ed Hurt and Markus Kunzler},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 17},
  pages={15397-405}
}
The small Ras-like GTPase Ran plays an essential role in the transport of macromolecules in and out of the nucleus and has been implicated in spindle (1,2 ) and nuclear envelope formation (3,4 ) during mitosis in higher eukaryotes. We identified Saccharomyces cerevisiae open reading frame YGL164c encoding a novel RanGTP-binding protein, termed Yrb30p. The protein competes with yeast RanBP1 (Yrb1p) for binding to the GTP-bound form of yeast Ran (Gsp1p) and is, like Yrb1p, able to form trimeric… CONTINUE READING