Identification and characterization of a novel retroviral-like aspartic protease specifically expressed in human epidermis.

@article{Bernard2005IdentificationAC,
  title={Identification and characterization of a novel retroviral-like aspartic protease specifically expressed in human epidermis.},
  author={Dominique Bernard and Bruno M{\'e}hul and Agn{\'e}s Thomas-Collignon and Caroline Delattre and Maryanne Donovan and Rainer Schmidt},
  journal={The Journal of investigative dermatology},
  year={2005},
  volume={125 2},
  pages={
          278-87
        }
}
Proteases play a pivotal role in epidermal differentiation and desquamation. Separation of a total protein extract from human reconstructed epidermis by two-dimensional gel electrophoresis and subsequent peptide analysis of a specific protein spot identified a new protein exhibiting similarities with the retroviral aspartic protease family. Cloning of the corresponding full-length cDNA revealed an open reading frame encoding for a new protease of 343 amino acids, containing a putative aspartic… Expand
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