Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes.

@article{Nicoll1999IdentificationAC,
  title={Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes.},
  author={Gavin Nicoll and Jing Ni and Dan Liu and Paul Klenerman and James R Munday and S Dubock and M. G. Matt{\'e}i and Paul R. Crocker},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 48},
  pages={34089-95}
}
We describe the characterization of sialic acid-binding Ig-like lectin-7 (siglec-7), a novel member of the siglec subgroup of the immunoglobulin superfamily. A full-length cDNA encoding siglec-7 was isolated from a human primary dendritic cell cDNA library. Siglec-7 is predicted to contain three extracellular immunoglobulin-like domains that comprise an N-terminal V-set domain and two C2-set domains, a transmembrane region and a cytoplasmic tail containing two tyrosine residues embodied in… CONTINUE READING

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