Identification and characterization of a novel genomic island integrated at selC in locus of enterocyte effacement-negative, Shiga toxin-producing Escherichia coli.

@article{Schmidt2001IdentificationAC,
  title={Identification and characterization of a novel genomic island integrated at selC in locus of enterocyte effacement-negative, Shiga toxin-producing Escherichia coli.},
  author={Herbert Schmidt and Wen Zhang and U Hemmrich and Srdjan Jela{\vc}i{\'c} and Werner Brunder and Phillip I Tarr and Ulrich Dobrindt and Joerg Hacker and Helge Karch},
  journal={Infection and immunity},
  year={2001},
  volume={69 11},
  pages={6863-73}
}
The selC tRNA gene is a common site for the insertion of pathogenicity islands in a variety of bacterial enteric pathogens. We demonstrate here that Escherichia coli that produces Shiga toxin 2d and does not harbor the locus of enterocyte effacement (LEE) contains, instead, a novel genomic island. In one representative strain (E. coli O91:H(-) strain 4797/97), this island is 33,014 bp long and, like LEE in E. coli O157:H7, is integrated 15 bp downstream of selC. This E. coli O91:H(-) island… CONTINUE READING