Corpus ID: 2040673

Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent.

@article{Obukowicz1998IdentificationAC,
  title={Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent.},
  author={M. Obukowicz and A. Raz and P. D. Pyla and J. Rico and J. Wendling and P. Needleman},
  journal={Biochemical pharmacology},
  year={1998},
  volume={55 7},
  pages={
          1045-58
        }
}
The anti-inflammatory properties of essential fatty acid deficiency or n-3 polyunsaturated fatty acid supplementation have been attributed to a reduced content of arachidonic acid (AA; 20:4 n-6). An alternative, logical approach to depleting AA would be to decrease endogenous synthesis of AA by selectively inhibiting the delta5 and/or the delta6 fatty acid desaturase. High-throughput radioassays were developed for quantifying delta5, delta6, and delta9 desaturase activities in vitro and in vivo… Expand
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