Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis.

@article{Sakakibara2004IdentificationAC,
  title={Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis.},
  author={Tomohiro Sakakibara and Yasuo Nemoto and Toshihiro Nukiwa and Hiroshi Takeshima},
  journal={FEBS letters},
  year={2004},
  volume={566 1-3},
  pages={
          294-300
        }
}
Cbl-interacting protein of 85 kDa (CIN85) is a recently identified adaptor protein involved in the endocytic process of several receptor tyrosine kinases. Here we have identified a novel RhoGAP, CIN85 associated multi-domain containing Rho1 (CAMGAP1) as a binding protein for CIN85. CAMGAP1 is composed of an Src homology 3 (SH3) domain, multiple WW domains, a proline-rich region, a PH domain and a RhoGAP domain, and has the domain architecture similar to ARHGAP9 and ARHGAP12. CAMGAP1 mRNA is… CONTINUE READING