Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2.

@article{Delany2001IdentificationAC,
  title={Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2.},
  author={N S Delany and Mark Hurle and Paul Facer and Tanja Alnadaf and Chris Plumpton and Ian J. Kinghorn and Chee Gee See and Michael Costigan and Priyanka Anand and Clifford J Woolf and Dalemari Crowther and Philippe Sanseau and Simon N. Tate},
  journal={Physiological genomics},
  year={2001},
  volume={4 3},
  pages={165-74}
}
Remarkable progress has been made recently in identifying a new gene family related to the capsaicin (vanilloid) receptor, VR1. Using a combination of in silico analysis of expressed sequence tag (EST) databases and conventional molecular cloning, we have isolated a novel vanilloid-like receptor, which we call VRL-2, from human kidney. The translated gene shares 46% and 43% identity with VR1 and VRL-1, respectively, and maps to chromosome 12q23-24.1, a locus associated with bipolar affective… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 29 references

Cloning of a stretch-inhibitable nonselective cation channel.

The Journal of biological chemistry • 1999
View 3 Excerpts
Highly Influenced

Acid potentiation of the capsaicin receptor determined by a key extracellular site.

Proceedings of the National Academy of Sciences of the United States of America • 2000
View 1 Excerpt

Molecular cloning , tissue distribution , and chromosomal mapping of the human epithelial Ca 2 1 channel

D Müller, Hoenderop JGJ, +7 authors Bindels RJM
Genomics • 2000

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