Identification and characterization of a membrane receptor for proteolysis-inducing factor on skeletal muscle.

@article{Todorov2007IdentificationAC,
  title={Identification and characterization of a membrane receptor for proteolysis-inducing factor on skeletal muscle.},
  author={Penio T. Todorov and Stacey M. Wyke and Michael John Tisdale},
  journal={Cancer research},
  year={2007},
  volume={67 23},
  pages={11419-27}
}
Proteolysis-inducing factor (PIF) is a sulfated glycoprotein produced by cachexia-inducing tumors, which induces atrophy of skeletal muscle. PIF has been shown to bind specifically with high affinity (K(d), in nanomolar) to sarcolemma membranes from skeletal muscle of both the mouse and the pig, as well as murine myoblasts and a human muscle cell line. Ligand binding was abolished after enzymatic deglycosylation, suggesting that binding was mediated through the oligosaccharide chains in PIF… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

For whom the bell tolls? DING proteins in health and disease

Cellular and Molecular Life Sciences • 2009
View 6 Excerpts
Highly Influenced

The DING family of proteins: ubiquitous in eukaryotes, but where are the genes?

BioEssays : news and reviews in molecular, cellular and developmental biology • 2009
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 37 references

The proteolysis-inducing factor: in search of its clinical relevance in patients with metastatic gastric/esophageal cancer.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus • 2006
View 1 Excerpt

DING proteins are from Pseudomonas.

FEMS microbiology letters • 2005
View 1 Excerpt

Characterization of a human homologue of proteolysis-inducing factor and its role in cancer cachexia.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2004
View 1 Excerpt

A neural survival factor is a candidate oncogene in breast cancer.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 1 Excerpt

Similar Papers

Loading similar papers…