Identification and characterization of a membrane receptor for proteolysis-inducing factor on skeletal muscle.

  title={Identification and characterization of a membrane receptor for proteolysis-inducing factor on skeletal muscle.},
  author={Penio T. Todorov and Stacey M. Wyke and Michael John Tisdale},
  journal={Cancer research},
  volume={67 23},
Proteolysis-inducing factor (PIF) is a sulfated glycoprotein produced by cachexia-inducing tumors, which induces atrophy of skeletal muscle. PIF has been shown to bind specifically with high affinity (K(d), in nanomolar) to sarcolemma membranes from skeletal muscle of both the mouse and the pig, as well as murine myoblasts and a human muscle cell line. Ligand binding was abolished after enzymatic deglycosylation, suggesting that binding was mediated through the oligosaccharide chains in PIF… CONTINUE READING


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