Identification and characterization of a mammalian protein interacting with 20S proteasome precursors.

@article{Burri2000IdentificationAC,
  title={Identification and characterization of a mammalian protein interacting with 20S proteasome precursors.},
  author={Lena Burri and J{\"o}rg H{\"o}ckendorff and Ulrich Boehm and Thorsten Klamp and R. J{\"u}rgen Dohmen and Fr{\'e}d{\'e}ric L{\'e}vy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 19},
  pages={10348-53}
}
The assembly of individual mammalian proteasome subunits into catalytically active 20S proteasome is not well understood. Herein, we report the identification and characterization of human and mouse homologues of the yeast proteasome maturating factor Ump1p. We delineate the region of hUMP1 implicated in the specific interaction with proteasome precursors and show that hUMP1 protein is absent from the mature form of the 20S proteasome. We also show that the transcript level of mammalian UMP1 is… CONTINUE READING

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