Identification and characterization of a major cell wall-associated iron-regulated envelope protein (Irep-28) in Mycobacterium tuberculosis.

@article{Yeruva2006IdentificationAC,
  title={Identification and characterization of a major cell wall-associated iron-regulated envelope protein (Irep-28) in Mycobacterium tuberculosis.},
  author={Veena C Yeruva and S. Duggirala and Velaga Lakshmi and Daniel Kolarich and Friedrich Altmann and M Sritharan},
  journal={Clinical and vaccine immunology : CVI},
  year={2006},
  volume={13 10},
  pages={
          1137-42
        }
}
Iron limitation and the expression of mycobactin and carboxymycobactin by Mycobacterium tuberculosis are known. Here, we report how iron regulated the coordinate expression of these two siderophores and a 28-kDa cell wall-associated iron-regulated protein (Irep-28). Irep-28 is identified as the DNA-binding HU homologue HupB protein (hupB [Rv2986c]). Antibodies to this protein were detected in sera from tuberculosis patients. The location of the protein in the cell wall makes it a potential drug… CONTINUE READING

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