Identification and characterization of a low oxygen response element involved in the hypoxic induction of a family of Saccharomyces cerevisiae genes. Implications for the conservation of oxygen sensing in eukaryotes.

@article{Vasconcelles2001IdentificationAC,
  title={Identification and characterization of a low oxygen response element involved in the hypoxic induction of a family of Saccharomyces cerevisiae genes. Implications for the conservation of oxygen sensing in eukaryotes.},
  author={Michael J. Vasconcelles and Ying Jiang and Kevin McDaid and Laura Gilooly and Sharon Wretzel and David L. Porter and Charles E. Martin and Mark P. Goldberg},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 17},
  pages={14374-84}
}
An organism's ability to respond to changes in oxygen tension depends in large part on alterations in gene expression. The oxygen sensing and signaling mechanisms in eukaryotic cells are not fully understood. To further define these processes, we have studied the Delta9 fatty acid desaturase gene OLE1 in Saccharomyces cerevisiae. We have confirmed previous data showing that the expression of OLE1 mRNA is increased in hypoxia and in the presence of certain transition metals. OLE1 expression was… CONTINUE READING
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