Identification and characterization of a hemolysin gene cluster in Vibrio anguillarum.

@article{Rock2006IdentificationAC,
  title={Identification and characterization of a hemolysin gene cluster in Vibrio anguillarum.},
  author={Jessica L Rock and David R. Nelson},
  journal={Infection and immunity},
  year={2006},
  volume={74 5},
  pages={2777-86}
}
Vibrio anguillarum is a causative agent of vibriosis in fish. Hemolytic activity has been suggested as a virulence factor by contributing to hemorrhagic septicemia and diarrhea. In order to identify and characterize the hemolysin genes and examine the role of hemolytic activity in virulence, a mini-Tn10Kan mutagenesis clone bank of V. anguillarum was screened. While no hemolysin-negative strains were observed, several mutants with two- to threefold-increased hemolytic activity were found. The… CONTINUE READING