Identification and characterization of a haploid germ cell-specific nuclear protein kinase (Haspin) in spermatid nuclei and its effects on somatic cells.

@article{Tanaka1999IdentificationAC,
  title={Identification and characterization of a haploid germ cell-specific nuclear protein kinase (Haspin) in spermatid nuclei and its effects on somatic cells.},
  author={Hiromitsu Tanaka and Yukihiro Yoshimura and Masami Nozaki and Kentaro Yomogida and Junji Tsuchida and Yasuhiro Tosaka and Toshiyuki Habu and Toshiyuki Nakanishi and Michiyo Okada and Hiroshi Nojima and Yoshitake Nishimune},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 24},
  pages={17049-57}
}
We have cloned the entire coding region of a mouse germ cell-specific cDNA encoding a unique protein kinase whose catalytic domain contains only three consensus subdomains (I-III) instead of the normal 12. The protein possesses intrinsic Ser/Thr kinase activity and is exclusively expressed in haploid germ cells, localizing only in their nuclei, and was thus named Haspin (for haploid germ cell-specific nuclear protein kinase). Western blot analysis showed that specific antibodies recognized a… CONTINUE READING

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