Identification and characterization of a phospholipase D-superfamily gene in rickettsiae.

@article{Renesto2003IdentificationAC,
  title={Identification and characterization of a phospholipase D-superfamily gene in rickettsiae.},
  author={Patricia Renesto and P. Dehoux and Edith Gouin and Lhousseine Touqui and Pascale Cossart and Didier Raoult},
  journal={The Journal of infectious diseases},
  year={2003},
  volume={188 9},
  pages={1276-83}
}
The completion of the sequencing of the genomes of both Rickettsia conorii and R. prowazekii provides the opportunity to identify putative virulence factors within these strictly intracellular pathogens. A role for a phospholipase A(2) (PLA(2)) in rickettsial pathogenicity was hypothesized, but the corresponding gene has not been identified. We have identified a gene that encodes a putative phospholipase D (PLD) and that has been detected by Southern blotting in 11 analyzed strains of… CONTINUE READING