Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest.

  title={Identification and characterization of a gene encoding a gut-enriched Kr{\"u}ppel-like factor expressed during growth arrest.},
  author={Janiel M. Shields and R. J. Christy and Vincent W. Yang},
  journal={The Journal of biological chemistry},
  volume={271 33},
A cDNA clone, named gut-enriched Krüppel-like factor (GKLF), was isolated from an NIH 3T3 library using a probe encoding the zinc finger region of the immediate-early transcription factor zif/268. The deduced GKLF amino acid sequence contains three tandem zinc fingers that are related to members of the Krüppel family of transcription factors. By indirect immunofluorescence, GKLF is localized to the cell nucleus. In cultured fibroblasts, GKLF mRNA is found in high levels in growth-arrested cells… CONTINUE READING