Identification and characterization of a fish natural resistance-associated macrophage protein (NRAMP) cDNA

@article{Saeij1999IdentificationAC,
  title={Identification and characterization of a fish natural resistance-associated macrophage protein (NRAMP) cDNA},
  author={Jeroen P J Saeij and Geert Frits Wiegertjes and Ren{\'e} J. M. Stet},
  journal={Immunogenetics},
  year={1999},
  volume={50},
  pages={60-66}
}
 The mouse Lsh/Ity/Bcg locus regulates natural resistance to intracellular pathogens, and the Nramp1 gene was isolated as its candidate. Nramp is part of a small family of at least two genes, Nramp1 and Nramp2. In the present study, a full-length cDNA for carp NRAMP has been isolated and characterized. Nucleotide and predicted amino acid sequence analysis indicate that the carp NRAMP encodes a 548 amino acid membrane protein with 12 putative transmembrane domains, two N-linked glycosylation… CONTINUE READING

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