Identification and characterization of a cyclooxygenase-like enzyme from Entamoeba histolytica.

@article{Dey2003IdentificationAC,
  title={Identification and characterization of a cyclooxygenase-like enzyme from Entamoeba histolytica.},
  author={Indranil Dey and Kathy Keller and Adam C Belley and Kris Chadee},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 23},
  pages={13561-6}
}
The intestinal protozoan parasite Entamoeba histolytica remains a significant cause of morbidity and mortality worldwide. However, almost nothing is known about the molecules secreted by the parasite that modulate host immune responses or epithelial barrier function in the colon. Herein, we describe the isolation and characterization of a cyclooxygenase (COX)-like enzyme in E. histolytica that is responsible for the biosynthesis of prostaglandin (PG)E2. PGE2 produced by ameba was constitutive… CONTINUE READING