Identification and characterization of a G protein-coupled receptor for the neuropeptide proctolin in Drosophilamelanogaster.

@article{Johnson2003IdentificationAC,
  title={Identification and characterization of a G protein-coupled receptor for the neuropeptide proctolin in Drosophilamelanogaster.},
  author={Erik C B Johnson and Stephen F. Garczynski and Dongkook Park and Joe W. Crim and Dick R Nassel and Paul H Taghert},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 10},
  pages={6198-203}
}
Proctolin is a bioactive neuropeptide that modulates interneuronal and neuromuscular synaptic transmission in a wide variety of arthropods. We present several lines of evidence to propose that the orphan G protein-coupled receptor CG6986 of Drosophila is a proctolin receptor. When expressed in mammalian cells, CG6986 confers second messenger activation after proctolin application, with an EC(50) of 0.3 nM. In competition-based studies, the CG6986 receptor binds proctolin with high affinity (IC… CONTINUE READING
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