Identification and characterization of T-cell antigen receptor-related genes in phylogenetically diverse vertebrate species

@article{Rast1995IdentificationAC,
  title={Identification and characterization of T-cell antigen receptor-related genes in phylogenetically diverse vertebrate species},
  author={Jonathan P. Rast and Robert N. Haire and Ronda T. Litman and Susan H Pross and Gary W. Litman},
  journal={Immunogenetics},
  year={1995},
  volume={42},
  pages={204-212}
}
Characterization of the structure, multiplicity, organization, and cell lineage-specific expression of T-cell receptor (TCR) genes of nonmammalian vertebrate species is central to the understanding of the evolutionary origins of rearranging genes of the vertebrate immune system. We recently described a polymerase chain reaction (PCR) strategy that relies on short sequence similarities shared by nearly all vertebrate TCR and immunoglobulin (Ig) variable (V) regions and have used this approach to… CONTINUE READING
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