Identification and characterization of SnrA, an inducible oxygen-insensitive nitroreductase in Salmonella enterica serovar Typhimurium TA1535.

@article{Nokhbeh2002IdentificationAC,
  title={Identification and characterization of SnrA, an inducible oxygen-insensitive nitroreductase in Salmonella enterica serovar Typhimurium TA1535.},
  author={M R Nokhbeh and Shahram Boroumandi and Nicholas J. Pokorny and Peter Koziarz and Elizabeth. paterson and Iain B Lambert},
  journal={Mutation research},
  year={2002},
  volume={508 1-2},
  pages={59-70}
}
The biological activity of many nitrosubstituted compounds, many of which are produced commercially or have been identified as environmental contaminants, is dependent on metabolic activation catalyzed by nitroreductases. In the current study, we have cloned a nitroreductase gene, Salmonella typhimurium nitroreductase A (snrA), from S. enterica serovar Typhimurium strain TA1535, and characterized the purified gene product. SnrA is 240 amino acids in length and shares 87% sequence identity to… CONTINUE READING