Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1

  title={Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1},
  author={Masahiro Kimura and Yoichi Matsuda and T. Yoshioka and Naoyuki Sumi and Yukio Okano},
  journal={Cytogenetic and Genome Research},
  pages={147 - 152}
Mutations in aurora of Drosophila and related Saccharomyces cerevisiae IPL1 protein kinases are known to cause abnormal chromosome segregation. We earlier isolated a cDNA encoding a novel human protein kinase Aik which shares high amino acid identity with the Aurora/Ipl1 protein kinase family. In the present study, a second human cDNA highly homologous to aurora/IPL1 (Aik2) was identified and the nucleotide sequence was determined (gene symbol STK12). The C-terminal kinase domain of the STK12… 

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