Identification and characterization of trimethylamine N-oxide (TMAO) demethylase and TMAO permease in Methylocella silvestris BL2.

@article{Zhu2014IdentificationAC,
  title={Identification and characterization of trimethylamine N-oxide (TMAO) demethylase and TMAO permease in Methylocella silvestris BL2.},
  author={Yijun Zhu and Eleanor Jameson and Rosemary A. Parslow and Ian Lidbury and Tiantian Fu and Timothy R. Dafforn and Hendrik Sch{\"a}fer and Yin Chen},
  journal={Environmental microbiology},
  year={2014},
  volume={16 10},
  pages={3318-30}
}
Methylocella silvestris, an alphaproteobacterium isolated from a forest soil, can grow on trimethylamine N-oxide (TMAO) as a sole nitrogen source; however, the molecular and biochemical mechanisms underpinning its growth remain unknown. Marker-exchange mutagenesis enabled the identification of several genes involved in TMAO metabolism, including Msil_3606, a permease of the amino acids-polyamine (APC) superfamily, and Msil_3603, consisting of an N-terminal domain of unknown function (DUF1989… CONTINUE READING
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