Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression.

@article{Prawitt2000IdentificationAC,
  title={Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression.},
  author={Dirk Prawitt and Thorsten Enklaar and Gerhard Klemm and Barbara Gaertner and Christian Spangenberg and Andreas Winterpacht and Michael J Higgins and Jerry Pelletier and Bernhard Zabel},
  journal={Human molecular genetics},
  year={2000},
  volume={9 2},
  pages={203-16}
}
Alterations within human chromosomal region 11p15.5 are associated with the Beckwith-Wiedemann syndrome (BWS) and predisposition to a variety of neoplasias, including Wilms' tumors (WTs), rhabdoid tumors and rhabdomyosarcomas. To identify candidate genes for 11p15. 5-related diseases we compared human genomic sequence with expressed sequence tag and protein databases from different organisms to discover evolutionarily conserved sequences. Herein we describe the identification and… CONTINUE READING

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