Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE.

@article{Wang1996IdentificationAC,
  title={Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE.},
  author={Sam Wang and Masayuki Miura and Yong Keun Jung and Hong-Jian Zhu and V Gagliardini and Lei Shi and Arnold H. Greenberg and J Yuan},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 34},
  pages={20580-7}
}
We report here the isolation and characterization of a new member of the ice/ced-3 family of cell death genes, named ich-3. The predicted amino acid sequence of Ich-3 protein shares 54% identity with murine interleukin-1beta converting enzyme (ICE). Overexpression of ich-3 in Rat-1 and HeLa cells induces apoptosis, which can be inhibited by CrmA and Bcl-2. The mRNA and proteins of ich-3 are dramatically induced in vivo upon stimulation with lipopolysaccharide, an inducer of septic shock. The… CONTINUE READING
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