Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37.

@article{Scholz2001IdentificationAC,
  title={Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37.},
  author={Glen M Scholz and Kellie A. Cartledge and Nathan E. Hall},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 33},
  pages={30971-9}
}
Although little is known about the precise mechanisms by which the molecular chaperone Hsp90 recognizes its client proteins, Cdc37 has been shown to play a critical role in the targeting of Hsp90 to client protein kinases. Described here is the identification and characterization of a novel 35-kDa human protein that is 31% identical to Cdc37. We have named this novel protein Harc (Hsp90-associating relative of Cdc37). Northern blot analysis revealed the presence of Harc mRNA in several human… CONTINUE READING