Identification and characterization of E. coli CRISPR‐cas promoters and their silencing by H‐NS

@article{Pul2010IdentificationAC,
  title={Identification and characterization of E. coli CRISPR‐cas promoters and their silencing by H‐NS},
  author={{\"U}mit Pul and R. Wurm and Zihni Arslan and Ren{\'e} Geissen and Nina Hofmann and R. Wagner},
  journal={Molecular Microbiology},
  year={2010},
  volume={75}
}
Inheritable bacterial defence systems against phage infection and foreign DNA, termed CRISPR (clustered regularly interspaced short palindromic repeats), consist of cas protein genes and repeat arrays interspaced with sequences originating from invaders. The Cas proteins together with processed small spacer‐repeat transcripts (crRNAs) cause degradation of penetrated foreign DNA by unknown mechanisms. Here, we have characterized previously unidentified promoters of the Escherichia coli CRISPR… Expand
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