Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription.

@article{Aldridge1995IdentificationAC,
  title={Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription.},
  author={Tom Aldridge and Jonathan D. Tugwood and Stephen M Green},
  journal={The Biochemical journal},
  year={1995},
  volume={306 ( Pt 2)},
  pages={473-9}
}
We have identified a peroxisome proliferator response element (PPRE) approx. 4300 nucleotide upstream of the rat cytochrome P-450 CYP4A1 gene. Two members of the steroid-hormone-receptor superfamily, the peroxisome proliferator-activated receptor-alpha (PPAR alpha) and the retinoid X receptor-alpha (RXR alpha), bind specifically to this element as a heterodimer, and this element confers responsiveness to the peroxisome proliferator Wyeth-14,643 when tested in co-transfection assays. A second… CONTINUE READING
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