Identification and characterization of CYP3A4*20, a novel rare CYP3A4 allele without functional activity.

@article{WestlindJohnsson2006IdentificationAC,
  title={Identification and characterization of CYP3A4*20, a novel rare CYP3A4 allele without functional activity.},
  author={Anna Westlind-Johnsson and Robert Hermann and Andreas Huennemeyer and Bernhard Hauns and Gezim Lahu and N. A. S. Nassr and Karl Zech and Magnus Ingelman-Sundberg and Oliver von Richter},
  journal={Clinical pharmacology and therapeutics},
  year={2006},
  volume={79 4},
  pages={339-49}
}
BACKGROUND The major drug-metabolizing enzyme cytochrome P450 (CYP) 3A4 is genetically conserved. One outlier of Brazilian descent was found in a clinical pharmacokinetic trial exhibiting a 6-fold higher exposure than expected to an investigational drug, shown to be a CYP3A4 substrate. We aimed to investigate the genetic background of this finding. METHODS The allelic variant of the CYP3A4 gene present in the outlier was sequenced, and the corresponding complementary deoxyribonucleic acid was… CONTINUE READING

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