Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection.

@article{Jong2007IdentificationAC,
  title={Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection.},
  author={Ambrose Y. Jong and Chun-hua Wu and Han-Min Chen and Feng Luo and Kyung J. Kwon-Chung and Yun C. Chang and Craig W Lamunyon and Anna Plaas and Sheng-He Huang},
  journal={Eukaryotic cell},
  year={2007},
  volume={6 8},
  pages={1486-96}
}
Cryptococcus neoformans is a pathogenic yeast that often causes devastating meningoencephalitis in immunocompromised individuals. We have previously identified the C. neoformans CPS1 gene, which is required for a capsular layer on the outer cell wall. In this report, we investigate the function of the CPS1 gene and its pathogenesis. We demonstrated that treatment of yeast with either 4-methylumbelliferone or hyaluronidase resulted in a reduction of the level of C. neoformans binding to human… CONTINUE READING
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