Identification and characterization of 2 types of erythroid progenitors that express GATA-1 at distinct levels.

@article{Suzuki2003IdentificationAC,
  title={Identification and characterization of 2 types of erythroid progenitors that express GATA-1 at distinct levels.},
  author={Norio Suzuki and Naruyoshi Suwabe and Osamu Ohneda and Naoshi Obara and Shigehiko Imagawa and Xiaoqing Pan and Hozumi Motohashi and Masayuki Yamamoto},
  journal={Blood},
  year={2003},
  volume={102 10},
  pages={
          3575-83
        }
}
Transcription factor GATA-1 is essential for the development of the erythroid lineage. To ascertain whether strict control of GATA-1 expression level is necessary for achieving proper erythropoiesis, we established transgenic mouse lines expressing green fluorescent protein (GFP) under the control of the GATA-1 gene hematopoietic regulatory domain. We examined the GATA-1 expression level by exploiting the transgenic mice and found 2 GFP-positive hematopoietic progenitor fractions in the bone… 
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Dynamic regulation of Gata factor levels is more important than their identity.
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