Identification and characterisation of constitutional chromosome abnormalities using arrays of bacterial artificial chromosomes

@article{Cowell2004IdentificationAC,
  title={Identification and characterisation of constitutional chromosome abnormalities using arrays of bacterial artificial chromosomes},
  author={John K Cowell and Yanping Wang and Karen Head and Jeffrey M. Conroy and Devin E. McQuaid and Norma J. Nowak},
  journal={British Journal of Cancer},
  year={2004},
  volume={90},
  pages={860 - 865}
}
Constitutional chromosome deletions and duplications frequently predispose to the development of a wide variety of cancers. We have developed a microarray of 6000 bacterial artificial chromosomes for array-based comparative genomic hybridisation, which provides an average resolution of 750 kb across the human genome. Using these arrays, subtle gains and losses of chromosome regions can be detected in constitutional cells, following a single overnight hybridisation. In this report, we… CONTINUE READING