Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons.

@article{Smith2010IdentificationAC,
  title={Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons.},
  author={Katharine R Smith and Peter L Oliver and Michael J. Lumb and I. Lorena Arancibia-C{\'a}rcamo and Raquel Revilla-Sanchez and Nicholas J. Brandon and Stephen J. Moss and Josef T Kittler},
  journal={Molecular and cellular neurosciences},
  year={2010},
  volume={44 4},
  pages={330-41}
}
The majority of fast inhibitory synaptic transmission in the mammalian nervous system is mediated by GABA(A) receptors (GABA(A)Rs). Here we report a novel interaction between the protein Maf1 and GABA(A)R beta-subunit intracellular domains. We find Maf1 to be highly expressed in brain and enriched in the hippocampus and cortex. In heterologous cells and neurons we show Maf1 co-localises with GABA(A)Rs in intracellular compartments and at the cell surface. In neurons, Maf1 is found localised in… CONTINUE READING