Identification and characterisation of a new human glucose-6-phosphatase isoform.

@article{Guionie2003IdentificationAC,
  title={Identification and characterisation of a new human glucose-6-phosphatase isoform.},
  author={Olivier Guionie and Eric Clottes and Kirsten Stafford and Ann Burchell},
  journal={FEBS letters},
  year={2003},
  volume={551 1-3},
  pages={159-64}
}
The liver endoplasmic reticulum glucose-6-phosphatase catalytic subunit (G6PC1) catalyses glucose 6-phosphate hydrolysis during gluconeogenesis and glycogenolysis. The highest glucose-6-phosphatase activities are found in the liver and the kidney; there have been many reports of glucose 6-phosphate hydrolysis in other tissues. We cloned a new G6Pase isoform (G6PC3) from human brain encoded by a six-exon gene (chromosome 17q21). G6PC3 protein was able to hydrolyse glucose 6-phosphate in… CONTINUE READING