Identification and biophysical characterization of a very-long-chain-fatty-acid-substituted phosphatidylinositol in yeast subcellular membranes.

@article{Schneiter2004IdentificationAB,
  title={Identification and biophysical characterization of a very-long-chain-fatty-acid-substituted phosphatidylinositol in yeast subcellular membranes.},
  author={Roger Schneiter and Britta Bruegger and Clare M Amann and Glenn D. Prestwich and Richard M Epand and Guenther Zellnig and Felix Theodor Wieland},
  journal={The Biochemical journal},
  year={2004},
  volume={381 Pt 3},
  pages={941-9}
}
Morphological analysis of a conditional yeast mutant in acetyl-CoA carboxylase acc1ts/mtr7, the rate-limiting enzyme of fatty acid synthesis, suggested that the synthesis of C26 VLCFAs (very-long-chain fatty acids) is important for maintaining the structure and function of the nuclear membrane. To characterize this C26-dependent pathway in more detail, we have now examined cells that are blocked in pathways that require C26. In yeast, ceramide synthesis and remodelling of GPI… CONTINUE READING

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Lipid rafts : elusive or illusive ?

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