Identification and biological evaluation of grapefruit oil components as potential novel efflux pump modulators in methicillin-resistant Staphylococcus aureus bacterial strains.

@article{Abulrob2004IdentificationAB,
  title={Identification and biological evaluation of grapefruit oil components as potential novel efflux pump modulators in methicillin-resistant Staphylococcus aureus bacterial strains.},
  author={Abedel-nasser G. Abulrob and Marc T. E. Suller and Mark Gumbleton and Claire Simons and A. Denver Russell},
  journal={Phytochemistry},
  year={2004},
  volume={65 22},
  pages={3021-7}
}
Methicillin-resistant Staphylococcus aureus (MRSA) and MSSA strains were treated with: (a) grapefruit oil (GFO) components, isolated by chromatography and characterised by NMR and mass spectroscopy; (b) antimicrobial agents, or (c) a combination of both to evaluate (MIC determination) intrinsic antibacterial activity and to determine whether GFO components could modulate bacterial sensitivity to the anti-bacterial agents. Preliminary data suggested that the grapefruit component 4-[[(E)-5-(3,3… CONTINUE READING

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