Identification and biological consequences of the O-GlcNAc modification of the human innate immune receptor, Nod2.

Abstract

Nucleotide-binding oligomerization domain 2 (Nod2) is an intracellular receptor that can sense the bacterial peptidoglycan component, muramyl dipeptide. Upon activation, Nod2 induces the production of various inflammatory molecules such as cytokines and chemokines. Genetic linkage analysis identified and revealed three major mutations in Nod2 that are… (More)
DOI: 10.1093/glycob/cwv076

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